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Results: 1-12 |
Results: 12
Toward the identification of gamma-secretase: Using transition state analog inhibitors
Authors: Esler, WP Kimberly, WT Ostaszewski, BL Xia, WM Selkoe, DJ Wolfe, MS
Citation: Wp. Esler et al., Toward the identification of gamma-secretase: Using transition state analog inhibitors, ALZHEIMER'S DISEASE, 2001, pp. 777-788
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
Authors: Esler, WP Kimberly, WT Ostaszewski, BL Diehl, TS Moore, CL Tsai, JY Rahmati, T Xia, WM Selkoe, DJ Wolfe, MS
Citation: Wp. Esler et al., Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1, NAT CELL BI, 2(7), 2000, pp. 428-434
FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: Evidence for direct involvement of PS1 in the gamma-secretase cleavage complex
Authors: Xia, WM Ostaszewski, BL Kimberly, WT Rahmati, T Moore, CL Wolfe, MS Selkoe, DJ
Citation: Wm. Xia et al., FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: Evidence for direct involvement of PS1 in the gamma-secretase cleavage complex, NEUROBIOL D, 7(6), 2000, pp. 673-681
Presenilin-mediated modulation of capacitative calcium entry
Authors: Yoo, AS Cheng, I Chung, S Grenfell, TZ Lee, H Pack-Chung, E Handler, M Shen, J Xia, WM Tesco, G Saunders, AJ Ding, K Frosch, MP Tanzi, RE Kim, TW
Citation: As. Yoo et al., Presenilin-mediated modulation of capacitative calcium entry, NEURON, 27(3), 2000, pp. 561-572
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
Authors: Xia, WM Ray, WJ Ostaszewski, BL Rahmati, T Kimberly, WT Wolfe, MS Zhang, JM Goate, AM Selkoe, DJ
Citation: Wm. Xia et al., Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation, P NAS US, 97(16), 2000, pp. 9299-9304
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling
Authors: Berezovska, O Jack, C McLean, P Aster, JC Hicks, C Xia, WM Wolfe, MS Kimberly, WT Weinmaster, G Selkoe, DJ Hyman, BT
Citation: O. Berezovska et al., Aspartate mutations in presenilin and gamma-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling, J NEUROCHEM, 75(2), 2000, pp. 583-593
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation
Authors: Kimberly, WT Xia, WM Rahmati, T Wolfe, MS Selkoe, DJ
Citation: Wt. Kimberly et al., The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation, J BIOL CHEM, 275(5), 2000, pp. 3173-3178
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
Authors: Wolfe, MS Xia, WM Ostaszewski, BL Diehl, TS Kimberly, WT Selkoe, DJ
Citation: Ms. Wolfe et al., Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity, NATURE, 398(6727), 1999, pp. 513-517
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including A beta 42
Authors: Perez, RG Soriano, S Hayes, JD Ostaszewski, B Xia, WM Selkoe, DJ Chen, XH Stokin, GB Koo, EH
Citation: Rg. Perez et al., Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including A beta 42, J BIOL CHEM, 274(27), 1999, pp. 18851-18856
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
Authors: Wolfe, MS De los Angeles, J Miller, DD Xia, WM Selkoe, DJ
Citation: Ms. Wolfe et al., Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease, BIOCHEM, 38(35), 1999, pp. 11223-11230
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
Authors: Wolfe, MS Xia, WM Moore, CL Leatherwood, DD Ostaszewski, B Rahmati, T Donkor, IO Selkoe, DJ
Citation: Ms. Wolfe et al., Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease, BIOCHEM, 38(15), 1999, pp. 4720-4727
Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi
Authors: Xia, WM Zhang, JM Ostaszewski, BL Kimberly, WT Seubert, P Koo, EH Shen, J Selkoe, DJ
Citation: Wm. Xia et al., Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi, BIOCHEM, 37(47), 1998, pp. 16465-16471
Risultati: 1-12 |