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Results: 1-23 |
Results: 23
Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I
Authors: Liao, S Shenderovich, M Kover, KE Zhang, Z Hosohata, K Davis, P Porreca, F Yamamura, HI Hruby, VJ
Citation: S. Liao et al., Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I, J PEPT RES, 57(4), 2001, pp. 257-276
Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation
Authors: Rubenzik, M Varga, E Stropova, D Roeske, WR Yamamura, HI
Citation: M. Rubenzik et al., Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation, MOLEC PHARM, 60(5), 2001, pp. 1076-1082
Biological properties of Phe(o)-opioid peptide analogues
Authors: Lipkowski, AW Misicka, A Hosohata, K Davis, P Yamamura, HI Porreca, F Hruby, VJ
Citation: Aw. Lipkowski et al., Biological properties of Phe(o)-opioid peptide analogues, LIFE SCI, 68(8), 2001, pp. 969-972
Mutation W284L of the human delta opioid receptor reveals agonist specificreceptor conformations for G protein activation
Authors: Hosohata, Y Varga, EV Stropova, D Li, XP Knapp, RJ Hruby, VJ Rice, KC Nagase, H Roeske, WR Yamamura, HI
Citation: Y. Hosohata et al., Mutation W284L of the human delta opioid receptor reveals agonist specificreceptor conformations for G protein activation, LIFE SCI, 68(19-20), 2001, pp. 2233-2242
Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE)
Authors: Witt, KA Huber, JD Egleton, RD Roberts, MJ Bentley, MD Guo, LH Wei, HB Yamamura, HI Davis, TP
Citation: Ka. Witt et al., Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE), J PHARM EXP, 298(2), 2001, pp. 848-856
Cannabinoid CB1 receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues
Authors: Stamer, WD Golightly, SF Hosohata, Y Ryan, EP Porter, AC Varga, E Noecker, RJ Felder, CC Yamamura, HI
Citation: Wd. Stamer et al., Cannabinoid CB1 receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues, EUR J PHARM, 431(3), 2001, pp. 277-286
Coupling of human delta-opioid receptor to retinal rod transducin in Chinese hamster ovary cells
Authors: Varga, EV Stropova, D Kim, T Wang, M Roeske, WR Yamamura, HI
Citation: Ev. Varga et al., Coupling of human delta-opioid receptor to retinal rod transducin in Chinese hamster ovary cells, J PHARM EXP, 292(1), 2000, pp. 209-214
Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin
Authors: Witt, KA Slate, CA Egleton, RD Huber, JD Yamamura, HI Hruby, VJ Davis, TP
Citation: Ka. Witt et al., Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin, J NEUROCHEM, 75(1), 2000, pp. 424-435
Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays
Authors: Bonner, GG Davis, P Stropova, D Edsall, S Yamamura, HI Porreca, F Hruby, VJ
Citation: Gg. Bonner et al., Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays, J MED CHEM, 43(4), 2000, pp. 569-580
Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability
Authors: Bilsky, EJ Egleton, RD Mitchell, SA Palian, MM Davis, P Huber, JD Jones, H Yamamura, HI Janders, J Davis, TP Porreca, F Hruby, VJ Polt, R
Citation: Ej. Bilsky et al., Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability, J MED CHEM, 43(13), 2000, pp. 2586-2590
The role of the G protein gamma(2) subunit in opioid antinociception in mice
Authors: Hosohata, K Logan, JK Varga, E Burkey, TH Vanderah, TW Porreca, F Hruby, VJ Roeske, WR Yamamura, HI
Citation: K. Hosohata et al., The role of the G protein gamma(2) subunit in opioid antinociception in mice, EUR J PHARM, 392(3), 2000, pp. R9-R11
delta-opioid receptor agonists produce antinociception and [S-35]GTP gammaS binding in mu receptor knockout mice
Authors: Hosohata, Y Vanderah, TW Burkey, TH Ossipov, MH Kovelowski, CJ Sora, I Uhl, GR Zhang, XY Rice, KC Roeske, WR Hruby, VJ Yamamura, HI Lai, J Porreca, F
Citation: Y. Hosohata et al., delta-opioid receptor agonists produce antinociception and [S-35]GTP gammaS binding in mu receptor knockout mice, EUR J PHARM, 388(3), 2000, pp. 241-248
Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin
Authors: Okura, T Cowell, SM Varga, E Burkey, TH Roeske, WR Hruby, VJ Yamamura, HI
Citation: T. Okura et al., Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin, EUR J PHARM, 387(2), 2000, pp. R11-R13
Improved bioavailability to the brain of glycosylated Met-enkephalin analogs
Authors: Egleton, RD Mitchell, SA Huber, JD Janders, J Stropova, D Polt, R Yamamura, HI Hruby, VJ Davis, TP
Citation: Rd. Egleton et al., Improved bioavailability to the brain of glycosylated Met-enkephalin analogs, BRAIN RES, 881(1), 2000, pp. 37-46
Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: New structural insights into receptor-ligand interactions
Authors: Salamon, Z Cowell, S Varga, E Yamamura, HI Hruby, VJ Tollin, G
Citation: Z. Salamon et al., Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: New structural insights into receptor-ligand interactions, BIOPHYS J, 79(5), 2000, pp. 2463-2474
Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and Metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors
Authors: Bartosz-Bechowski, H Davis, P Slaninova, J Malatynska, E Stropova, D Porreca, F Yamamura, HI Hruby, VJ
Citation: H. Bartosz-bechowski et al., Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and Metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors, J PEPT RES, 53(3), 1999, pp. 329-336
Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin
Authors: Lipkowski, AW Misicka, A Davis, P Stropova, D Janders, J Lachwa, M Porreca, F Yamamura, HI Hruby, VJ
Citation: Aw. Lipkowski et al., Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin, BIOORG MED, 9(18), 1999, pp. 2763-2766
The delta-opioid receptor: Molecular pharmacology, signal transduction, and the determination of drug efficacy
Authors: Quock, RM Burkey, TH Varga, E Hosohata, Y Hosohata, K Cowell, SM Slate, CA Ehlert, FJ Roeske, WR Yamamura, HI
Citation: Rm. Quock et al., The delta-opioid receptor: Molecular pharmacology, signal transduction, and the determination of drug efficacy, PHARM REV, 51(3), 1999, pp. 503-532
Exploring the structure-activity relationships of [1-(4-tert-butyl-3 '-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand
Authors: Alfaro-Lopez, J Okayama, T Hosohata, K Davis, P Porreca, F Yamamura, HI Hruby, VJ
Citation: J. Alfaro-lopez et al., Exploring the structure-activity relationships of [1-(4-tert-butyl-3 '-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand, J MED CHEM, 42(26), 1999, pp. 5359-5368
(2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor
Authors: Hosohata, K Burkey, TH Alfaro-Lopez, J Hruby, VJ Roeske, WR Yamamura, HI
Citation: K. Hosohata et al., (2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor, EUR J PHARM, 380(1), 1999, pp. R9-R10
Phosphorylation of adenylyl cyclase VI upon chronic delta-opioid receptor stimulation
Authors: Varga, EV Stropova, D Rubenzik, M Waite, S Roeske, WR Yamamura, HI
Citation: Ev. Varga et al., Phosphorylation of adenylyl cyclase VI upon chronic delta-opioid receptor stimulation, EUR J PHARM, 364(2-3), 1999, pp. R1-R3
Pharmacological characterization of glucocorticoid receptors in primary human bronchial epithelial cells
Authors: LeVan, TD Babin, EA Yamamura, HI Bloom, JW
Citation: Td. Levan et al., Pharmacological characterization of glucocorticoid receptors in primary human bronchial epithelial cells, BIOCH PHARM, 57(9), 1999, pp. 1003-1009
Structural correlates for down-regulation of m1 and m2 muscarinic receptorsubtypes
Authors: Malatynska, E Waite, S Wei, HB Knapp, RJ Yamamura, HI Roeske, WR
Citation: E. Malatynska et al., Structural correlates for down-regulation of m1 and m2 muscarinic receptorsubtypes, BRAIN RES B, 47(3), 1998, pp. 285-290
Risultati: 1-23 |