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Results: 1-10 |
Results: 10
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties
Authors: Liu, G Huth, JR Olejniczak, ET Mendoza, R DeVries, P Leitza, S Reilly, EB Okasinski, GF Fesik, SW von Geldern, TW
Citation: G. Liu et al., Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties, J MED CHEM, 44(8), 2001, pp. 1202-1210
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide
Authors: Winn, M Reilly, EB Liu, G Huth, JR Jae, HS Freeman, J Pei, ZH Xin, ZL Lynch, J Kester, J von Geldern, TW Leitza, S DeVries, P Dickinson, R Mussatto, D Okasinski, GF
Citation: M. Winn et al., Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide, J MED CHEM, 44(25), 2001, pp. 4393-4403
New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models
Authors: Szczepankiewicz, BG Liu, G Jae, HS Tasker, AS Gunawardana, IW von Geldern, TW Gwaltney, SL Wu-Wong, JR Gehrke, L Chiou, WJ Credo, RB Alder, JD Nukkala, MA Zielinski, NA Jarvis, K Mollison, KW Frost, DJ Bauch, JL Hui, YH Claiborne, AK Li, Q Rosenberg, SH
Citation: Bg. Szczepankiewicz et al., New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models, J MED CHEM, 44(25), 2001, pp. 4416-4430
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ETA antagonists
Authors: Jae, HS Winn, M von Geldern, TW Sorensen, BK Chiou, WJ Nguyen, B Marsh, KC Opgenorth, TJ
Citation: Hs. Jae et al., Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ETA antagonists, J MED CHEM, 44(23), 2001, pp. 3978-3984
Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides
Authors: Pei, ZH Xin, ZL Liu, G Li, YH Reilly, EB Lubbers, NL Huth, JR Link, JT von Geldern, TW Cox, BF Leitza, S Gao, Y Marsh, KC DeVries, P Okasinski, GF
Citation: Zh. Pei et al., Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides, J MED CHEM, 44(18), 2001, pp. 2913-2920
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead
Authors: Liu, G Link, JT Pei, ZH Reilly, EB Leitza, S Nguyen, B Marsh, KC Okasinski, GF von Geldern, TW Ormes, M Fowler, K Gallatin, M
Citation: G. Liu et al., Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead, J MED CHEM, 43(21), 2000, pp. 4025-4040
Discovery of a series of pyrrolidine-based endothelin receptor antagonistswith enhanced ETA receptor selectivity
Authors: Boyd, SA Mantei, RA Tasker, AS Liu, G Sorensen, BK Henry, KJ von Geldern, TW Winn, M Wu-Wong, JSR Chiou, WJ Dixon, DB Hutchins, CW Marsh, KC Nguyen, E Opgenorth, TJ
Citation: Sa. Boyd et al., Discovery of a series of pyrrolidine-based endothelin receptor antagonistswith enhanced ETA receptor selectivity, BIO MED CH, 7(6), 1999, pp. 991-1002
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ETB selectivity
Authors: von Geldern, TW Tasker, AS Sorensen, BK Winn, M Szczepankiewicz, BG Dixon, DB Chiou, WJ Wang, LM Wessale, JL Adler, A Marsh, KC Nguyen, E Opgenorth, TJ
Citation: Tw. Von Geldern et al., Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ETB selectivity, J MED CHEM, 42(18), 1999, pp. 3668-3678
Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ETB antagonists containing a diphenylmethylamine acetamide side chain
Authors: Liu, G Kozmina, NS Winn, M von Geldern, TW Chiou, WJ Dixon, DB Nguyen, E Marsh, KC Opgenorth, TJ
Citation: G. Liu et al., Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ETB antagonists containing a diphenylmethylamine acetamide side chain, J MED CHEM, 42(18), 1999, pp. 3679-3689
Pharmacology of A-216546: a highly selective antagonist for endothelin ETAreceptor
Authors: Wu-Wong, JSR Dixon, DB Chiou, WJ Dayton, BD Novosad, EI Adler, AL Wessale, JL Calzadilla, SV Hernandez, L Marsh, KC Liu, G Szczepankiewicz, B von Geldern, TW Opgenorth, TJ
Citation: Jsr. Wu-wong et al., Pharmacology of A-216546: a highly selective antagonist for endothelin ETAreceptor, EUR J PHARM, 366(2-3), 1999, pp. 189-201
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