T. Ohta et al., INHIBITORY EFFECT OF A SERINE-PROTEASE INHIBITOR, FOY-305 ON THE INVASION AND METASTASIS OF HUMAN PANCREATIC CANCERS, International journal of oncology, 11(4), 1997, pp. 813-817
We examined the inhibitory effect of a serine protease inhibitor, FOY-
305, on the invasion and metastasis of human pancreatic cancers. The i
n vitro matrigel invasion assay showed that the invasiveness of Capan-
1 human pancreatic cancer cells was inhibited by FOY-305 treatment in
a dose-dependent manner at concentrations greater than 100 nM. Intrasp
lenic injection of Capan-1 cells in nude mice resulted in frequent met
astases to liver, however, its incidence was significantly decreased b
y FOY-305 treatment. These findings suggest that a serine protease inh
ibitor, FOY-305 can inhibit tumor invasion and metastasis by blocking
the serine protease-mediated activation cascade.