2ND PRIMARY MALIGNANCIES AFTER SMALL-CELLLUNG-CANCER

The records of 1,371 patients with small cell carcinoma of the lung (S CLC) treated between 1983 and 1994, were reviewed for the occurrence o f second primary malignancies (SPM). One was excluded for analysis bec ause of insufficient data. Eight synchronous SPM (SSPM) and 8 metachro nous SPM (MSPM) were identified. SSPM included non-small cell lung can cer in 6 patients, 1 head and neck cancer and 1 oesophageal cancer. Me dian survival after the diagnosis of SSPM was 6 months. The MSPM were detected between 1 and 6 years after the diagnosis of SCLC. MSPM inclu ded lung cancer (3 patients), gastrointestinal malignancies (2 patient s), 1 hematologic malignancy, 1 prostatic cancer and 1 head and neck c ancer. The median survival time after the diagnosis of MSPM was 4 mont hs. Occurrence of SPM is a singular pattern of patients with SCLC. Tob acco consumption, genetic factors and carcinogenic effects of multimod ality treatment are supposed mechanisms to explain SPM.