PROTEIN-KINASE-C AND TUMORIGENIC POTENTIAL

Initially described as a unique entity, protein kinase C (PKC) is now represented by a family of 11 isoforms which differ in their structura l and biochemical properties as well as in their tissular distribution subcellular localization and substrate specificity. So far a lot of s tudies have attempted to approach the role of each of these PKC isofor ms in the deregulation of growth signaling that leads to carcinogenesi s. Among the various strategies developed, the surexpression of specif ic isoforms in different cellular models is the strategy which led to major advances as concern the PKC-cancer relationship. This review rep orts the main results obtained in this field especially in that of col orectal cancer.