ISOLATION AND CHARACTERIZATION OF NOVEL CYTOTOXIC SAPONINS FROM ARCHIDENDRON ELLIPTICUM

Authors
BEUTLER JA KASHMAN Y PANNELL LK CARDELLINA JH ALEXANDER MRA BALASCHAK MS PRATHER TR SHOEMAKER RH BOYD MR
Citation
Ja. Beutler et al., ISOLATION AND CHARACTERIZATION OF NOVEL CYTOTOXIC SAPONINS FROM ARCHIDENDRON ELLIPTICUM, Bioorganic & medicinal chemistry, 5(8), 1997, pp. 1509-1517
Citations number
32
Categorie Soggetti
Biology,"Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
5
Issue
8
Year of publication
1997
Pages
1509 - 1517
Database
ISI
SICI code
0968-0896(1997)5:8<1509:IACONC>2.0.ZU;2-S
Abstract
A series of new ester saponins, elliptosides A-J, has been isolated fr om the tropical plant Archidendron ellipticum (Leguminosae). These sap onins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structur es of elliptosides A, E, and F were elucidated by spectroscopic and ch emical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line. Published by Elsevier Science Ltd.