NARROW-BORE LIQUID-CHROMATOGRAPHIC ASSAY FOR OXCARBAZEPINE AND ITS MAJOR METABOLITE IN RAT-BRAIN, LIVER AND BLOOD MICRODIALYSATES

Authors
VANBELLE K DEKOSTER V SARRE S EBINGER G MICHOTTE Y
Citation
K. Vanbelle et al., NARROW-BORE LIQUID-CHROMATOGRAPHIC ASSAY FOR OXCARBAZEPINE AND ITS MAJOR METABOLITE IN RAT-BRAIN, LIVER AND BLOOD MICRODIALYSATES, Journal of chromatography B. Biomedical applications, 657(1), 1994, pp. 149-154
Citations number
13
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography B. Biomedical applications
ISSN journal
15726495 → ACNP
Volume
657
Issue
1
Year of publication
1994
Pages
149 - 154
Database
ISI
SICI code
Abstract
An isocratic narrow-bore high-performance liquid chromatographic assay with UV detection is described for the detection of oxcarbazepine and its major metabolite, 10,11-dihydro-10-hydroxycarbamazepine, using ca rbamazepine as the internal standard. This method is sufficiently sens itive to allow quantification of oxcarbazepine and its metabolite in r at brain, liver and blood microdialysates.