RENAL OSMOREGULATORY TRANSPORT OF COMPATIBLE ORGANIC OSMOLYTES

Cells in renal medullas are exposed to a high concentration of salt du ring antidiuresis. They adapt in part by accumulating myo-inositol, gl ycine betaine, taurine, and other amino acids by transporting them fro m the interstitial fluid. This transport is osmotically regulated by c hanges in transcription of the transporters and by post-translational modifications. Most of the original studies were in vitro, but these p rocesses are increasingly being examined in vivo.