HYPERHOMOCYSTEINEMIA - DETECTION, RISK ASSESSMENT, AND TREATMENT

Citation
Vw. Dennis et al., HYPERHOMOCYSTEINEMIA - DETECTION, RISK ASSESSMENT, AND TREATMENT, Current opinion in nephrology and hypertension, 6(5), 1997, pp. 483-488
Citations number
47
Categorie Soggetti
Urology & Nephrology","Peripheal Vascular Diseas
ISSN journal
10624821
Volume
6
Issue
5
Year of publication
1997
Pages
483 - 488
Database
ISI
SICI code
1062-4821(1997)6:5<483:H-DRAA>2.0.ZU;2-Y
Abstract
Homocysteine is formed by the demethylation of methionine in the cours e of its normal metabolism. Hyperhomocysteinemia is an independent ris k factor for vascular disease. It develops most commonly from folate d eficiency, genetic abnormalities, and chronic renal failure. Current m odels favor direct angiotoxicity involving endothelial and vascular sm ooth muscle cells, and impaired thrombolysis. Folic acid reduces hyper homocysteinemia and thus provides an opportunity for risk-factor modif ication.