CHANGES IN LIVER DRUG GLUCURONIDATION DURING CHOLESTASIS ARE NON PREDICTABLE

Authors
OUVINA GB LEMBERG A BENGOCHEA LA
Citation
Gb. Ouvina et al., CHANGES IN LIVER DRUG GLUCURONIDATION DURING CHOLESTASIS ARE NON PREDICTABLE, ARCH I PHYS, 102(2), 1994, pp. 121-123
Citations number
12
Categorie Soggetti
Physiology,Biology,Biophysics
Journal title
Archives internationales de physiologie, de biochimie et de biophysique
ISSN journal
07783124 → ACNP
Volume
102
Issue
2
Year of publication
1994
Pages
121 - 123
Database
ISI
SICI code
0778-3124(1994)102:2<121:CILDGD>2.0.ZU;2-X
Abstract
Liver microsomal glucuronidation of acetaminophen, chloramphenicol, sa licylic acid, lorazepam, p-nitrophenol and morphine were measured in 8 days bile duct ligated rats. Compared to normals, cholestatic rats sh owed a decrease of 31% for p-nitrophenol glucuronidation; salicylic ac id glucuronidation increased 281%; acetaminophen glucuronidation incre ased 38% while morphine, chloramphenicol and lorazepam values were sim ilar to controls. We concluded that cholestasis produces non predictab le changes on liver drug glucuronidation pathways.