SYNERGISTIC ACTION OF VITAMIN-C AND AMINO-ACIDS ON VITAMIN-E IN INHIBITION OF THE LIPOPEROXIDATION OF LINOLEIC-ACID IN DISPERSE SYSTEMS

Citation
Me. Carlotti et al., SYNERGISTIC ACTION OF VITAMIN-C AND AMINO-ACIDS ON VITAMIN-E IN INHIBITION OF THE LIPOPEROXIDATION OF LINOLEIC-ACID IN DISPERSE SYSTEMS, International journal of pharmaceutics, 155(2), 1997, pp. 251-261
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
03785173
Volume
155
Issue
2
Year of publication
1997
Pages
251 - 261
Database
ISI
SICI code
0378-5173(1997)155:2<251:SAOVAA>2.0.ZU;2-5
Abstract
The synergistic effect of some amino acids (L-tryptophan, L-cysteine, L-alanine and glycine), glutathione, n-butylamine and of vitamin C on the antioxidant effect of vitamin E on the lipoperoxidation of linolei c acid in sodium dodecylsulphate micellar solutions and oil in water e mulsions was examined at pH 5.0 and 7.0. The antioxidant activity of v itamin E, measured by oxygen consumption, was similar in both emulsion s and micellar solutions. The addition of vitamin C produced only a sl ight synergistic effect at pH 5.0 and none, or a prooxidative effect, at pH 7.0. The amino acids studied exerted a synergistic effect only a t pH 5.0, and their effectiveness was partially related to their lipop hilicity. (C) 1997 Elsevier Science B.V.