Me. Carlotti et al., SYNERGISTIC ACTION OF VITAMIN-C AND AMINO-ACIDS ON VITAMIN-E IN INHIBITION OF THE LIPOPEROXIDATION OF LINOLEIC-ACID IN DISPERSE SYSTEMS, International journal of pharmaceutics, 155(2), 1997, pp. 251-261
The synergistic effect of some amino acids (L-tryptophan, L-cysteine,
L-alanine and glycine), glutathione, n-butylamine and of vitamin C on
the antioxidant effect of vitamin E on the lipoperoxidation of linolei
c acid in sodium dodecylsulphate micellar solutions and oil in water e
mulsions was examined at pH 5.0 and 7.0. The antioxidant activity of v
itamin E, measured by oxygen consumption, was similar in both emulsion
s and micellar solutions. The addition of vitamin C produced only a sl
ight synergistic effect at pH 5.0 and none, or a prooxidative effect,
at pH 7.0. The amino acids studied exerted a synergistic effect only a
t pH 5.0, and their effectiveness was partially related to their lipop
hilicity. (C) 1997 Elsevier Science B.V.