INVOLVEMENT OF TNF-ALPHA SECRETING MACROPHAGES IN LETHAL FORMS OF HUMAN GRAFT-VERSUS-HOST DISEASE

Authors
FACON T JOUET JP NOELWALTER MP BLOGET F BAUTERS F JANIN A
Citation
T. Facon et al., INVOLVEMENT OF TNF-ALPHA SECRETING MACROPHAGES IN LETHAL FORMS OF HUMAN GRAFT-VERSUS-HOST DISEASE, Bone marrow transplantation, 20(6), 1997, pp. 511-515
Citations number
21
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
20
Issue
6
Year of publication
1997
Pages
511 - 515
Database
ISI
SICI code
0268-3369(1997)20:6<511:IOTSMI>2.0.ZU;2-2
Abstract
We report three patients with lethal forms of acute GVHD in whom all b iopsy specimens showed a striking. preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha, The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the exi stence of primary macrophagic forms of GVHD is discussed.