UNSUCCESSFUL TREATMENT OF MISSED ABORTION WITH A COMBINATION OF AN ANTIPROGESTERONE AND A PROSTAGLANDIN E-1 ANALOG

In a prospective clinical trial the effectiveness of a combination of 400 mg of mifepristone (antiprogesterone) and 400 g misoprostol (synth etic prostaglandin E-1 analogue), both taken orally, was evaluated for the treatment of missed abortion. Of the 31 patients included, 16 (52 %) had an empty uterine cavity at follow up six days after inclusion, 11 (35%) required surgical evacuation for retained intrauterine produc ts of conception found at follow up, and four (13%) required emergency surgical evacuation due to severe pain or bleeding. The results do no t support the use of mifepristone and misoprostol for women wishing th e miscarriage to be resolved quickly.