PROPERTIES OF CYTOCHROME-P450 ISOENZYMES AND THEIR SUBSTRATES .1. ACTIVE-SITE CHARACTERISTICS

Authors
SMITH DA ACKLAND MJ JONES BC
Citation
Da. Smith et al., PROPERTIES OF CYTOCHROME-P450 ISOENZYMES AND THEIR SUBSTRATES .1. ACTIVE-SITE CHARACTERISTICS, Drug discovery today, 2(10), 1997, pp. 406-414
Citations number
48
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Drug discovery today → ACNP
ISSN journal
13596446
Volume
2
Issue
10
Year of publication
1997
Pages
406 - 414
Database
ISI
SICI code
1359-6446(1997)2:10<406:POCIAT>2.0.ZU;2-E
Abstract
Cytochrome P450 isoenzymes are pivotal in drug clearance. Protein homo logy modelling combined with studies on the structure and physico-chem istry of substrates is allowing the key factors governing selectivity for substrates to be ascertained. The knowledge gained will be used in future in the drug design process to produce compounds more resistant to metabolism or with lowered potential to inhibit the enzyme. Ultima tely therefore, the progress being made will result in the discovery a nd development of safer and more effective therapies.