A NEW ELECTROPHILIC ALANINOL SYNTHON - A GENERAL-ROUTE TO OXAZOLIDINONES OF D-2-AMINO OR (R)-2-AMINO ALCOHOLS FROM L-SERINE

Authors
SIBI MP RUTHERFORD D SHARMA R
Citation
Mp. Sibi et al., A NEW ELECTROPHILIC ALANINOL SYNTHON - A GENERAL-ROUTE TO OXAZOLIDINONES OF D-2-AMINO OR (R)-2-AMINO ALCOHOLS FROM L-SERINE, Journal of the Chemical Society. Perkin transactions. I, (13), 1994, pp. 1675-1678
Citations number
58
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
13
Year of publication
1994
Pages
1675 - 1678
Database
ISI
SICI code
0300-922X(1994):13<1675:ANEAS->2.0.ZU;2-3
Abstract
A new electrophilic alaninol synthon, (S)-4-(4'-tolylsulfonyloxymethyl ) oxazolidin-2-one, derived from serine, undergoes nucleophilic displa cements with Gilman cuprates and/or Grignard/CuX reagents in high yiel d to provide (R)-4-substituted oxazolidinones.