REGIOSELECTIVE HYDROLYSIS OF AROMATIC DINITRILES USING A WHOLE-CELL CATALYST

Authors
CROSBY J MOILLIET J PARRATT JS TURNER NJ
Citation
J. Crosby et al., REGIOSELECTIVE HYDROLYSIS OF AROMATIC DINITRILES USING A WHOLE-CELL CATALYST, Journal of the Chemical Society. Perkin transactions. I, (13), 1994, pp. 1679-1687
Citations number
57
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
13
Year of publication
1994
Pages
1679 - 1687
Database
ISI
SICI code
0300-922X(1994):13<1679:RHOADU>2.0.ZU;2-N
Abstract
A series of aromatic dinitriles have been; examined as substrates for an immobilised whole cell Rhodococcus sp. that catalyses the hydrolysi s of nitriles to amides and/or carboxylic acids. The fluorinated aroma tic dinitriles 48 and 49 were regioselectively hydrolysed to the corre sponding cyano amides 48a and 49a whereas the non-fluorinated analogue s 41-44 were converted to cyano acids but with poorer regioselectivity .