STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATES WITH BIFUNCTIONAL REAGENTS .2. STABILITY OF NUCLEOSIDE H-PHOSPHONATE DIESTERS IN THE PRESENCE OF AMINO-ALCOHOLS
M. Sobkowski et al., STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATES WITH BIFUNCTIONAL REAGENTS .2. STABILITY OF NUCLEOSIDE H-PHOSPHONATE DIESTERS IN THE PRESENCE OF AMINO-ALCOHOLS, Journal of the Chemical Society. Perkin transactions. I, (13), 1994, pp. 1803-1808
H Phosphonate diesters undergo transesterification with amino alcohols
to afford as primary products the mixed and the symmetrical H-phospho
nate esters. Alcohols react similarly but only in the presence of an e
xternal base or in a basic solvent. The rate and the course of transes
terification strongly depend on the reaction conditions, the reactivit
y of the H-phosphonate diester used. and the nature of the amino alcoh
ol.