STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATES WITH BIFUNCTIONAL REAGENTS .2. STABILITY OF NUCLEOSIDE H-PHOSPHONATE DIESTERS IN THE PRESENCE OF AMINO-ALCOHOLS

Citation
M. Sobkowski et al., STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATES WITH BIFUNCTIONAL REAGENTS .2. STABILITY OF NUCLEOSIDE H-PHOSPHONATE DIESTERS IN THE PRESENCE OF AMINO-ALCOHOLS, Journal of the Chemical Society. Perkin transactions. I, (13), 1994, pp. 1803-1808
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
ISSN journal
0300922X
Issue
13
Year of publication
1994
Pages
1803 - 1808
Database
ISI
SICI code
0300-922X(1994):13<1803:SORONH>2.0.ZU;2-A
Abstract
H Phosphonate diesters undergo transesterification with amino alcohols to afford as primary products the mixed and the symmetrical H-phospho nate esters. Alcohols react similarly but only in the presence of an e xternal base or in a basic solvent. The rate and the course of transes terification strongly depend on the reaction conditions, the reactivit y of the H-phosphonate diester used. and the nature of the amino alcoh ol.