ESTABLISHMENT OF A HUMAN SMALL-CELL LUNG-CANCER CELL-LINE PRODUCING ALARGE AMOUNT OF ANTI-DIURETIC HORMONE

A new cancer cell line (Lu-165) producing a large amount of anti-diure tic hormone (ADH, 2.8 mu g/g protein) was established from a 50-year-o ld small cell lung cancer patient presenting with a syndrome of inappr opriate anti-diuretic hormone secretion. These cells grew well in seru m-supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a us eful tool for studies of the biochemistry and pathology of ADH-produci ng cancer.