VALUE OF CYFRA-21-1, TPA, AND SCC-AG IN PREDICTING EXTRACERVICAL DISEASE AND PROGNOSIS IN CERVICAL-CANCER

Background: The value of serum Cyfra 21-1 level was compared with tiss ue polypeptide antigen (TPA), and squamous cell carcinoma antigen (SCC -Ag) in squamous cell cervical cancer Materials and Methods: PI e-and post-treatment serum levels of patients were compared with lymph node status, parametrial involvement, and prognostic data. Results: Pretrea tment serum levels of each marker were significantly related to tumor stage, tumor size and the presence of either lymph node metastases or parametrial involvement. The clinical performance of each marker in pr edicting extracervical disease at initial diagnosis appeared to be sim ilar. None of these tests achieved the conditions of a perfect test Pr etreatment serum levels of each marker showed prognostic value in the univariate analysis. The clinical performance of post-treatment SCC-Ag levels in predicting complete remission versus the presence of armor during follow-up was better than Cyfra 21-1 or TPA. Conclusion: SCC-Ag appears to be move useful than Cyfra 21-1 for monitoring patients wit h cervical cancer.