UGP - A TUMOR-MARKER OF GYNECOLOGIC AND BREAST MALIGNANCIES - SPECIFICITY AND SENSITIVITY IN PRETHERAPEUTIC PATIENTS AND THE INFLUENCE OF HORMONAL SUBSTITUTION ON THE EXPRESSION OF UGP
U. Schwarzroeger et al., UGP - A TUMOR-MARKER OF GYNECOLOGIC AND BREAST MALIGNANCIES - SPECIFICITY AND SENSITIVITY IN PRETHERAPEUTIC PATIENTS AND THE INFLUENCE OF HORMONAL SUBSTITUTION ON THE EXPRESSION OF UGP, Anticancer research, 17(4B), 1997, pp. 3041-3045
Urinary gonadotropin peptide (UGP) is a 10,300 Dalton peptide which is
present in the urine of pregnant women, those with trophoblast diseas
e and those with, certain nontrophoblastic malignancies. We examined t
he efficiency of UGP measurement at differentiating benign from malign
ant gynecologic and breast diseases. UGP was measured in 1355 spot win
e samples from 841 patients (343 samples from 323 healthy women and wo
men with benign gynecologic and breast diseases, 1012 samples from 528
women with gynecologic malignant diseases or breast cancer). Using a
cutoff of >3 fmol UGP/mg urinary creatinine the specificity was 97%. T
he sensitivity of UGP was calculated from pretherapeutically collected
samples (n = 210). The sensitivity of the test for all malignancies w
as 26% (ovarian malignancy (n = 27) 52%, endometrial cancer (n = 25) 3
2%, cervical cancer (n = 49) 29%, breast cancer (n = 72) 19%, vulvar c
ancer and vaginal cancer (n = 12) 17% and for carcinoma in situ of the
breast or the cervix (n = 20) 0%). We also found significantly higher
UGP values in postmenopausal women than in premenopausal women. Hormo
nal substitution significantly lowered the UGP values.