TRANSPLACENTAL PASSAGE OF ALUMINUM FROM PREGNANT MICE TO FETUS ORGANSAFTER MATERNAL TRANSCUTANEOUS EXPOSURE

Aluminium is present in tap water, antiperspirants and cosmetics up to 20%. Teratogenicity of aluminium was clearly identified after per os or intravenous administration. Malformations and other alterations by aluminium intoxication were evaluated in fetus. In the present study, we investigated the possible transplacental passage of aluminium and i ts accumulation in the tissue after cutaneous uptake. Female Swiss mic e received aluminium chloride by cutaneous way (0.4 mu g/day) during 2 0 days of gestation, The samples were assayed for aluminium quantifica tion by graphite furnace atomic absorption with Zeeman correction. Thi s treatment led to an increase of aluminium in maternal and fetus samp les (serum, amniotic fluid and organs) as compared to controls.