1,2,4-TRIAZOLES - IMPROVED SYNTHESIS OF 5-SUBSTITUTED 4-AMINO-3-MERCATO-(4H)-1,2,4-TRIAZOLES AND A FACILE ROUTE TO 3,6-DISUBSTITUTED 1,2,4-TRIAZOLO[3,4-B][1,3,4]THIADIAZOLES

Authors
INVIDIATA FP FURNO G LAMPRONTI I SIMONI D
Citation
Fp. Invidiata et al., 1,2,4-TRIAZOLES - IMPROVED SYNTHESIS OF 5-SUBSTITUTED 4-AMINO-3-MERCATO-(4H)-1,2,4-TRIAZOLES AND A FACILE ROUTE TO 3,6-DISUBSTITUTED 1,2,4-TRIAZOLO[3,4-B][1,3,4]THIADIAZOLES, Journal of heterocyclic chemistry, 34(4), 1997, pp. 1255-1258
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
4
Year of publication
1997
Pages
1255 - 1258
Database
ISI
SICI code
0022-152X(1997)34:4<1255:1-ISO5>2.0.ZU;2-Y
Abstract
The reaction of thiocarbohydrazide with carboxylic acids at the meltin g temperature allows an improved preparation of the 5-substituted 4-am ino-3-mercapto-1,2,4-triazole heterocycles. The crude 4-amino-5-mercap to-1,2,4-triazoles react easily with carboxylic acids or carboxylic ac id chlorides to afford the 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole rin g system.