SYNTHESIS AND REACTIONS OF 1-(2-OXOPROPYL)PYRIDAZIN-6-ONES

Authors
CHOI WY CHO SD KIM SK YOON YJ
Citation
Wy. Choi et al., SYNTHESIS AND REACTIONS OF 1-(2-OXOPROPYL)PYRIDAZIN-6-ONES, Journal of heterocyclic chemistry, 34(4), 1997, pp. 1307-1313
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
4
Year of publication
1997
Pages
1307 - 1313
Database
ISI
SICI code
0022-152X(1997)34:4<1307:SARO1>2.0.ZU;2-X
Abstract
Oxopropylation of 4,5-dihalopyridazin-6-ones with chloroacetone afford ed the corresponding 1-(2-oxo-propyl) derivatives. Reaction of title c ompound with nucleophiles such as amines, alkoxides were investigated. In addition, selective reduction of 3-nitro-1-(2-oxopropyl)pyridazin- 6-ones with iron/ammonium chloride in two phase solutions or zinc in a cetic acid gave the corresponding 3-amino or 3-hydroxyimino derivative s.