SYNTHESIS OF NEW FLUORINATED 1,5-BENZOXAZEPINE DERIVATIVES

Authors
COCCO MT CONGIU C ONNIS V BERNARD AM PIRAS PP
Citation
Mt. Cocco et al., SYNTHESIS OF NEW FLUORINATED 1,5-BENZOXAZEPINE DERIVATIVES, Journal of heterocyclic chemistry, 34(4), 1997, pp. 1347-1350
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
4
Year of publication
1997
Pages
1347 - 1350
Database
ISI
SICI code
0022-152X(1997)34:4<1347:SONF1D>2.0.ZU;2-2
Abstract
A simple approach to the fluorinated 1,5-benzoxazepine ring system is described. By reacting commercially accessible aminophenols 1 and the trifluoroacetylvinyl ether 2, high yields of enaminones 3 were obtaine d. Functionalization of methyl group of compounds 3 gave rise to diene amines 4 that were cyclized in acidic environment to benzoxazepine der ivatives 5.