A SHORT AND UNEQUIVOCAL SYNTHESIS OF 5-AMINOTETRAZOLO[1,5-A]QUINAZOLINE AS A TRICYCLIC ANALOG OF 4-(3-BROMOANILINO)6,7-DIMETHOXYQUINAZOLINE(PD-153035)

Authors
BENCTEUX E HOUSSIN R HENICHART JP
Citation
E. Bencteux et al., A SHORT AND UNEQUIVOCAL SYNTHESIS OF 5-AMINOTETRAZOLO[1,5-A]QUINAZOLINE AS A TRICYCLIC ANALOG OF 4-(3-BROMOANILINO)6,7-DIMETHOXYQUINAZOLINE(PD-153035), Journal of heterocyclic chemistry, 34(4), 1997, pp. 1375-1378
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
4
Year of publication
1997
Pages
1375 - 1378
Database
ISI
SICI code
0022-152X(1997)34:4<1375:ASAUSO>2.0.ZU;2-K
Abstract
The discovery of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 15303 5) as an extremely potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor led to the preparation of severa l fused tricyclic quinazoline analogues. The present paper reports a n ew tricyclic derivative: anilino)-7,8-dimethoxytetrazolo[1,5-a]quinazo line. This compound was synthesized by two different pathways via a 1, 3-dipolar cycloaddition of an azide at carbon 2 of the quinazoline rin g.