Leukocyte integrins and intercellular adhesion molecules play pivotal
roles in leukocyte adhesion to target cells and extracellular matrices
. Recently, novel intercellular adhesion molecules have been identifie
d, and much information has been obtained on the structures and bindin
g sites of leukocyte integrins and of intercellular adhesion molecules
. Furthermore, much progress has been made in the study of integrin ac
tivation and the role of leukocyte adhesion molecules in disease.