THE EZRIN PROTEIN FAMILY - MEMBRANE-CYTOSKELETON INTERACTIONS AND DISEASE ASSOCIATIONS

Ezrin, radixin, moesin and merlin form a subfamily of conserved protei ns in the band 4.1 superfamily. Ezrin protein subfamily members act as linkers between the plasma membrane and the cytoskeleton. Members of the subfamily have been shown to interact with each other, with cell a dhesion molecules such as CD44 and with F-actin. Recent data indicate that intercellular adhesion molecules 1 and 2 also interact with ezrin . The proteins are also involved in the redistribution of intercellula r adhesion molecules and the organization of cell membrane structures. Merlin is a tumor suppressor that is involved in tumorigenesis of sch wannomas and meningiomas. Merlin has the same overall protein structur e as the other proteins in the subfamily but may have partially distin ct functions.