Recent research concerning the contribution of intrauterine factors to
mental retardation has centered on two areas. The first area is fetal
alcohol syndrome. Underdiagnosis has been suspected for some time lar
gely because of the failure of paediatricians to always recognise the
subtle dysmorphism. More accurate recogniton of this has been facilita
ted by research in the past 12 months which should enhance the recogni
tion and diagnosis and reduce the number and percentage of remaining u
ndiagnosed cases of mental retardation. The second area is cerebral pa
lsy. It is well known that cerebral palsy is frequently accompanied by
learning difficulties and the same insult which causes the motor defi
cit in cerebral palsy is also responsible for the learning difficulty.
Recent research, particularly in the past 12 months, has recognised t
hat up to 40% of term and 20% of preterm babies have prepart origin fo
r their cerebral palsy and this represents another significant contrib
ution of previously unrecognised intrauterine events to the causation
of mental retardation.