Gg. Rimkus et al., CRITICAL CONSIDERATIONS ON THE ANALYSIS AND BIOACCUMULATION OF MUSK XYLENE AND OTHER SYNTHETIC NITRO MUSKS IN FISH, Chemosphere, 35(7), 1997, pp. 1497-1507
Several analytical methods for the residue analysis of musk xylene (MX
), musk ketone (MK), and other nitro musks in fish are presented and d
iscussed. In particular because of a publication about a fast and simp
le analysis without any clean-up procedure, the necessity of a thoroug
h clean-up of fat-containing samples is emphasized. In addition, the p
resent knowledge about the high bioconcentration of these lipophilic p
ollutants in fish is summarized. In a long-term bioconcentration study
we found in rainbow trouts bioconcentration factors (BCF) on a wet we
ight basis (BCFW) of MX from 4,200 to 5,100 while the BCF values on a
lipid basis (BCFL) ranged from 115,000 to 122,000. These BCF values of
MX are in good agreement with the BCF values calculated from the n-oc
tanol/water partition coefficient (log K-ow = 4.90) using the Quantita
tive Structure-Activity Relationship (QSAR). A published study with ex
tremely low bioconcentration factors of MX is critically discussed. (C
) 1997 Elsevier Science Ltd.