PERIVENTRICULAR HETEROTOPIAS DISPLAY CORTICAL DEGENERATIVE NEUROPATHOLOGY

This report describes beta-amyloid plaques in periventricular heteroto pias in two elderly women. The neuropathologic features of the heterot opias recapitulated those of nearby neocortex but were distinct from t hose of adjacent caudate nucleus. In response to the factors important in plaque and tangle formation, the heterotopias biologically behave like neocortex and unlike adjacent striatum, further supporting the mo rphologic evidence that these tissues represent heterotopic cortex.