CUMULATIVE MEAN CHANGE PROCEDURE - APPLICATION TO A COMPARATIVE TRIALOF VENLAFAXINE, IMIPRAMINE, AND PLACEBO IN THE TREATMENT OF MAJOR DEPRESSION

1. A simple summary measure - namely, cumulative mean change (CMC) - i s proposed for analyzing incomplete repeated measures in clinical sett ings. 2. A simple test statistic that uses the correlation between sub ject responses was derived and applied to a study comparing an investi gational antidepressant, venlafaxine, with imipramine and placebo. 3. The global fashion in which CMC captured all data confirmed the effica cy advantage of venlafaxine over the two control agents.