NEUROPATHOLOGY AND MOLECULAR STUDIES OF A PATIENT WITH TOURETTE-SYNDROME AND HUNTINGTON-DISEASE

This paper reviews the association of Huntington's Disease (HD) and ti c disorder or Tourette Syndrome (TS) We also present the results of a follow-up study of a male with childhood-onset TS and adult-onset HD w ho died at 45 yeats of age. The developmental course and results of ne uropathologic and molecular studies of this patient are reported. This is the first case of childhood onset of TS with adult onset of HD rep orted who has come to autopsy. A developmental model for childhood and adult neuropsychiatric disorders is presented.