1-THIO-BETA-D-GALACTOSE AS A CHIRAL DERIVATIZATION AGENT FOR THE RESOLUTION OF D,L-AMINO ACID ENANTIOMERS

Authors
JEGOROV A TRISKA J TRNKA T
Citation
A. Jegorov et al., 1-THIO-BETA-D-GALACTOSE AS A CHIRAL DERIVATIZATION AGENT FOR THE RESOLUTION OF D,L-AMINO ACID ENANTIOMERS, Journal of chromatography, 673(2), 1994, pp. 286-290
Citations number
15
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography → ACNP
Volume
673
Issue
2
Year of publication
1994
Pages
286 - 290
Database
ISI
SICI code
Abstract
o-Phthaldialdehyde in combination with 1-thio-beta-D-galactose is a po werful chiral reagent for the precolumn derivatization of primary amin o acids. The diastereomers formed can be efficiently resolved on conve ntional reversed-phase columns. Comparison of 1-thio-beta-D-galactose with 1-thio-beta-D-glucose revealed that even the change of the config uration of the remote OH group on the sugar moiety influences the reso lution of D,L-amino acid derivatives.