INFLUENCE OF DIETARY SORBOSE ON DIABETES IN NONOBESE DIABETIC MICE

The effect of dietary sorbose on diabetes after the incidence of the s yndrome in the nonobese diabetic mouse was investigated in the animals from 8 to 14 weeks of age. When sucrose (200 g/kg diet) in a control diet was replaced by sorbose, the body weight and the blood glucose co ncentration were significantly reduced, but the serum insulin concentr ation was unchanged. The urinary glucose concentration was the same fo r both sucrose and sorbose diets. It is suggested that after the incid ence of diabetes, dietary sorbose could not improve urinary excretion of glucose, even though sorbose could reduce the blood glucose concent ration.