Inflammatory bowel disease remains a poorly understood chronic inflamm
atory condition of the bowel. No etiologic agents, or agreed upon path
ogenesis is currently known. Recent findings that perinuclear antineut
rophil cytoplasmic antibodies (P-ANCA) are present in the vast majorit
y of patients with this disease have proven to be of use in epidemiolo
gic studies. Its clinical use is currently being explored by several i
nvestigators.