AUDIOGENIC-SEIZURES AFTER NECK TOURNIQUET-INDUCED CEREBRAL-ISCHEMIA IN THE RAT

Development of audiogenic seizures (AGS) and their correlation with ne urodegeneration were studied after 7.5 min of whole-brain ischemia. On e day post-ischemia, all animals became hyperreactive and responded to auditory stimulation by generalized seizures. Neuronal necrosis devel oped already 6 h post-ischemia in inferior colliculi, reticular thalam ic nucleus and hippocampal hilar region. Repeated ischemia did not ind uce any neurological changes, suggesting that the neurological effects are consequences of selective neuronal injury. (C) 1997 Elsevier Scie nce B.V.