IDENTIFICATION AND IN-VITRO IMMUNOSUPPRESSIVE ACTIVITY OF A SDZ-IMM-125 METABOLITE ISOLATED FROM PHENOBARBITAL-INDUCED RABBIT LIVER-MICROSOMES

Authors
DIEDEN R VERBEECK RK MATON N LATINNE D LHOEST GJJ
Citation
R. Dieden et al., IDENTIFICATION AND IN-VITRO IMMUNOSUPPRESSIVE ACTIVITY OF A SDZ-IMM-125 METABOLITE ISOLATED FROM PHENOBARBITAL-INDUCED RABBIT LIVER-MICROSOMES, Xenobiotica, 27(9), 1997, pp. 933-949
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Toxicology
Journal title
Xenobiotica → ACNP
ISSN journal
00498254
Volume
27
Issue
9
Year of publication
1997
Pages
933 - 949
Database
ISI
SICI code
0049-8254(1997)27:9<933:IAIIAO>2.0.ZU;2-J
Abstract
1. A metabolite of D-serine-cyclosporine A has been isolated from phen obarbital induced rabbit liver microsomes using hplc. 2. This metaboli te was identified by FAB, electrospray mass spectrometry as well as nm r spectroscopy and is the result of metabolism of the vinylic methyl g roup of the 9-carbon amino acid unique to the cyclosporins, the first amino acid of this cyclic undecapeptide. This metabolite exhibits a si gnificantly lower immunosuppressive activity than IMM-125 and CsA.