IMMUNOSUPPRESSIVE EFFECTS OF GALLIC ACID AND CHEBULAGIC ACID ON CTL-MEDIATED CYTOTOXICITY

Authors
HAMADA S KATAOKA T WOO JT YAMADA A YOSHIDA T NISHIMURA T OTAKE N NAGAI K
Citation
S. Hamada et al., IMMUNOSUPPRESSIVE EFFECTS OF GALLIC ACID AND CHEBULAGIC ACID ON CTL-MEDIATED CYTOTOXICITY, Biological & pharmaceutical bulletin, 20(9), 1997, pp. 1017-1019
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
20
Issue
9
Year of publication
1997
Pages
1017 - 1019
Database
ISI
SICI code
0918-6158(1997)20:9<1017:IEOGAA>2.0.ZU;2-4
Abstract
Gallic acid (GA) and chebulagic acid (CA) were isolated from the extra ct of a herbal medicine, kashi (myrobalans: the fruit of Terminalia ch ebula) as active principles that blocked the cytotoxic T lymphocyte (C TL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8(+) CTL clone at IC50 values of 30 mu M and 50 mu M, respectively, Granule exocytosis in response to anti-CD3 stimulation was also block ed by GA and CA at the equivalent concentrations.