S. Hamada et al., IMMUNOSUPPRESSIVE EFFECTS OF GALLIC ACID AND CHEBULAGIC ACID ON CTL-MEDIATED CYTOTOXICITY, Biological & pharmaceutical bulletin, 20(9), 1997, pp. 1017-1019
Gallic acid (GA) and chebulagic acid (CA) were isolated from the extra
ct of a herbal medicine, kashi (myrobalans: the fruit of Terminalia ch
ebula) as active principles that blocked the cytotoxic T lymphocyte (C
TL)-mediated cytotoxicity. GA and CA inhibited the killing activity of
CD8(+) CTL clone at IC50 values of 30 mu M and 50 mu M, respectively,
Granule exocytosis in response to anti-CD3 stimulation was also block
ed by GA and CA at the equivalent concentrations.