SYNTHESIS AND ANTITUMOR-ACTIVITY OF NOVEL BENZOPHENONE DERIVATIVES

Authors
KUMAZAWA E HIROTANI K BURFORD SC KAWAGOE K MIWA T MITSUI I EJIMA A
Citation
E. Kumazawa et al., SYNTHESIS AND ANTITUMOR-ACTIVITY OF NOVEL BENZOPHENONE DERIVATIVES, Chemical and Pharmaceutical Bulletin, 45(9), 1997, pp. 1470-1474
Citations number
3
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
9
Year of publication
1997
Pages
1470 - 1474
Database
ISI
SICI code
0009-2363(1997)45:9<1470:SAAONB>2.0.ZU;2-8
Abstract
Novel benzophenone derivatives were synthesized and screened for cytot oxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesize d, morpholino and thiomorpholino benzophenones 3a-d exhibited potent c ytotoxic activity against P388 murine leukemia and PC-6 human lung car cinoma cells in vitro, and compounds 3a. 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.