It. Ling et al., IMMUNIZATION AGAINST THE MURINE MALARIA PARASITE PLASMODIUM-YOELII USING A RECOMBINANT PROTEIN WITH ADJUVANTS DEVELOPED FOR CLINICAL USE, Vaccine, 15(14), 1997, pp. 1562-1567
Mice vaccinated with a recombinant protein containing the two EGF-like
modules of Plasmodium yoelii merozoite surface protien-1 in liposomes
or combined with the formulations SBAS2.1 and SBAS2, were protected a
gainst a lethal malaria infection. The protection achieved with these
adjuvants developed for clinical use was as good as or better than tha
t achieved with Freund's adjuvant. A parasite-specific response was ne
eded for protected. Analysis of the immunoglobulin sub-class response
showed that MSP-1-specific IgG1, and to a lesser extent IgG2a and IgG2
b, were induced, suggesting that these antibodies were important for p
rotection. Mice passively immunized with serum or purified IgG from va
ccinated mice had delayed onset of parasitemia and were able to contro
l the infection. (C) 1997 Elsevier Science Ltd.