IMMUNIZATION AGAINST THE MURINE MALARIA PARASITE PLASMODIUM-YOELII USING A RECOMBINANT PROTEIN WITH ADJUVANTS DEVELOPED FOR CLINICAL USE

Citation
It. Ling et al., IMMUNIZATION AGAINST THE MURINE MALARIA PARASITE PLASMODIUM-YOELII USING A RECOMBINANT PROTEIN WITH ADJUVANTS DEVELOPED FOR CLINICAL USE, Vaccine, 15(14), 1997, pp. 1562-1567
Citations number
38
Categorie Soggetti
Immunology
Journal title
ISSN journal
0264410X
Volume
15
Issue
14
Year of publication
1997
Pages
1562 - 1567
Database
ISI
SICI code
0264-410X(1997)15:14<1562:IATMMP>2.0.ZU;2-G
Abstract
Mice vaccinated with a recombinant protein containing the two EGF-like modules of Plasmodium yoelii merozoite surface protien-1 in liposomes or combined with the formulations SBAS2.1 and SBAS2, were protected a gainst a lethal malaria infection. The protection achieved with these adjuvants developed for clinical use was as good as or better than tha t achieved with Freund's adjuvant. A parasite-specific response was ne eded for protected. Analysis of the immunoglobulin sub-class response showed that MSP-1-specific IgG1, and to a lesser extent IgG2a and IgG2 b, were induced, suggesting that these antibodies were important for p rotection. Mice passively immunized with serum or purified IgG from va ccinated mice had delayed onset of parasitemia and were able to contro l the infection. (C) 1997 Elsevier Science Ltd.