UNUSUAL LACTAM FORMATION OCCURRING IN THE SYNTHESIS OF A BIOTINYLATEDT-ANTIGEN-SERINE DERIVATIVE

Authors
BAY S BERTHIERVERGNES O BIBEROVIC V CANTACUZENE D
Citation
S. Bay et al., UNUSUAL LACTAM FORMATION OCCURRING IN THE SYNTHESIS OF A BIOTINYLATEDT-ANTIGEN-SERINE DERIVATIVE, Carbohydrate research, 303(1), 1997, pp. 25-31
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Carbohydrate research → ACNP
ISSN journal
00086215
Volume
303
Issue
1
Year of publication
1997
Pages
25 - 31
Database
ISI
SICI code
0008-6215(1997)303:1<25:ULFOIT>2.0.ZU;2-4
Abstract
Synthesis of the biotinylated T-antigens, linked to a serine by an alp ha (7 alpha) or a beta (7 beta) 2-acetamido-2-deoxy-D-galactoside bond , is described. These derivatives were needed for the detection of a s pecific endogenous lectin at the surface and/or on the migration pathw ay of melanoma cells. In the course of the synthesis, an unusual lacta m formation was observed with the beta anomer of the azido-disaccharid e 5 beta. (C) 1997 Elsevier Science Ltd.