GRANULOMATOUS INTERSTITIAL NEPHRITIS AND UVEITIS PRESENTING AS SALT-LOSING NEPHROPATHY

Salt-wasting nephropathy is a rare syndrome in which renal insufficien cy is associated with extracellular volume depletion from marked natri uresis in the absence of adrenal insufficiency or diuretics, We report the clinical course of a 23-year-old woman with renal insufficiency, in association with orthostatic hypotension and salt wasting, A combin ation of daily infusion of saline, a high-salt diet and oral fludrocor tisone did not compensate for her salt loses. Renal biopsy showed nonc aseating granulomas and marked interstitial inflammation. Renal functi on and salt loss improved with prednisone therapy and 6 months after w ithdrawal of steroids, her renal function remains stable.