Previous research has documented differences in the pattern of EEG act
ivation between 3-month-old infants of depressed mothers and infants o
f nondepressed mothers. In the present study: EEG was recorded in even
younger 1-month-old infants of depressed and nondepressed mothers. Th
e infants of depressed mothers exhibited greater relative right fronta
l EEG asymmetry (due to reduced left frontal activation), and this pat
tern at 1 month was significantly related to 3-month EEG asymmetry. Ri
ght frontal EEG asymmetry was also related to more frequent negative f
acial expressions (sad and pre-cry faces) during the Brazelton exam. F
inally, the infants of depressed mothers showed more indeterminate sle
ep, were less active, and cried less than infants of nondepressed moth
ers.