SYNTHESIS, STRUCTURE AND ANTIACETYLCHOLINESTERASE ACTIVITY OF 4-BETA-METHOXYMETHYL-4-BETA-DEMETHYL TERRITREM-B

Authors
PENG FC CHENG JS
Citation
Fc. Peng et Js. Cheng, SYNTHESIS, STRUCTURE AND ANTIACETYLCHOLINESTERASE ACTIVITY OF 4-BETA-METHOXYMETHYL-4-BETA-DEMETHYL TERRITREM-B, Mycopathologia, 137(2), 1997, pp. 125-128
Citations number
16
Categorie Soggetti
Mycology,Pathology
Journal title
Mycopathologia → ACNP
ISSN journal
0301486X
Volume
137
Issue
2
Year of publication
1997
Pages
125 - 128
Database
ISI
SICI code
0301-486X(1997)137:2<125:SSAAAO>2.0.ZU;2-Q
Abstract
4 beta-Methoxymethyl-4 beta-demethyl territrem B [5] was synthesized f rom 4 beta-hydroxymethyl-beta-demethyl territrem B [4] by treatment wi th dimethyl sulfate in methanolic NaOH. The structure of 5 was elucida ted by uv, nmr and mass spectra. The IC50 of 5 on acetylcholinesterase (AChE) was 6.30 x 10(-5) M, which indicated 0.4% of the anti-AChE act ivity of territrem B [2].