A. Ueki et al., SYNAPSE ALTERATION IN HIPPOCAMPAL CA3 FIELD FOLLOWING ENTORHINAL CORTEX LESION, Journal of the neurological sciences, 151(1), 1997, pp. 1-5
To model one aspect of the neurodegeneration observed in Alzheimer's d
isease and to investigate the synaptic alteration of the hippocampus a
ssociated with entorhinal cortex lesion, ibotenic acid was used to pro
duce selective unilateral neuronal loss in rat entorhinal cortex. Immu
nohistological and microdensitometrical analyses confirmed ibotenic ac
id lesion of the entorhinal cortex after 3 months and showed a decreas
e of synaptophysin-immunoreactive substances in the stratum lucidum of
the CA3 field. This study demonstrates that entorhinal cortex lesion
can lead to synaptic alterations and cause damage to presynaptic termi
nals with projecting area in the disruption of the entorhinal cortex h
ippocampus relay passage. (C) 1997 Elsevier Science B.V.