CHANGES DURING THE LAST DECADE IN CLINICAL-PARAMETERS OF OPERATED LUNG-CARCINOMA PATIENTS OF A CENTER FOR THORACIC-SURGERY AND THE PROGNOSTIC-SIGNIFICANCE OF TNM, MORPHOMETRIC, CYTOMETRIC, AND GLYCOHISTOCHEMICAL PROPERTIES

Citation
K. Kayser et al., CHANGES DURING THE LAST DECADE IN CLINICAL-PARAMETERS OF OPERATED LUNG-CARCINOMA PATIENTS OF A CENTER FOR THORACIC-SURGERY AND THE PROGNOSTIC-SIGNIFICANCE OF TNM, MORPHOMETRIC, CYTOMETRIC, AND GLYCOHISTOCHEMICAL PROPERTIES, The thoracic and cardiovascular surgeon, 45(4), 1997, pp. 196-199
Citations number
25
Categorie Soggetti
Cardiac & Cardiovascular System",Surgery
ISSN journal
01716425
Volume
45
Issue
4
Year of publication
1997
Pages
196 - 199
Database
ISI
SICI code
0171-6425(1997)45:4<196:CDTLDI>2.0.ZU;2-T
Abstract
Two sets of patients with potentially curative resection of primary ca rcinomas operated in the Department of Thoracic Surgery, Thoraxklinik, Heidelberg during the period 1983-1984 (cohort I), and in 1994 (cohor t II) were analyzed. The survival of patients, postsurgical TNM-stages , cell types, and exposure to potentially harmful substances were eval uated. In addition, cytometric and morphometric techniques, and variou s biotinylated markers have been applied to the tissue sections of the 1994 cohort; Cohort I comprised 282 patients (253 men and 29 women), cohort II all in all 171 patients (121 men and 49 women). In cohort I there were 262 heavy smokers, and 28 patients had a history of exposur e to harmful enrivonmental substances (asbestos, polycyclic aromates, etc.) compared to 145 smokers and 68 patients who inhaled potentially harmful substances in cohort II. Major changes were also seen in early lung cancer stages (pT1, pN0) which increased in cohort II, and in a decrease in the relative frequency of epidermoid carcinomas in both me n and women with corresponding increase in the frequency of adenocarci noma in both sexes. The median survival of patients operated with adva nced tumor stages had remained unchanged, that of early stages (pT1, p N0, pN1) seems to have improved. Within the cytometric features syntac tic structure analysis revealed that the current of structural entropy is closely associated with the survival of patients. Of prognostic si gnificance are, in addition, the expression of binding capacities to h istoblood group trisaccharides A and H, the presence and the binding o f macrophage migration inhibitory factor, and the presence of ligands for the chicken liver galectin CL-16 and the Lewis(Y) antigen. Multiva riant statistical analysis gave preferential prognostic importance to the glycohistochemical and morphometric parameters relative to the cli nical pi and pN stages in survival analysis.