H. Bengtsson et al., MOLECULAR IMPRINT BASED RADIOASSAY FOR DIRECT DETERMINATION OF S-PROPRANOLOL IN HUMAN PLASMA, Analytical communications, 34(9), 1997, pp. 233-235
Molecular imprints of S-propranolol have been applied to the developme
nt of a radiolabelled assay, which is conceptually identical to radioi
mmunoassay, for direct determination of the concentration of S-propran
olol in biofluids. Determination of S-propranolol in human plasma and
urine was used as a model system. The imprint based assay measured pla
sma and urine concentrations in the range of 20 to 1000 nM with accura
cies of 89-107% and 91-125%, and precisions of 3-13% and 1-7%, respect
ively. The results demonstrate that it is possible to carry out molecu
lar imprint based assays of biological samples without prior sample cl
ean up.