The aim of the present study was to determine whether multiple scleros
is (MS) affects a person's ability to formulate message content in nar
rative discourse. Discourse samples were elicited from 47 persons with
MS and 47 matched controls in response to computer-generated, animate
d sequences. Within the conceptual level of discourse processing, data
were analysed for story schema and informative content. The two group
s, MS and control, could not be distinguished by measures of the quant
ity of information conveyed. However, results revealed a difference in
the nature of the information produced by the two groups. The persons
with MS produced less essential story information than control subjec
ts, while a tendency for the persons with MS to produce more incorrect
and ambiguous information than controls was also noted. A number of f
actors were considered in an attempt to explain the underlying source
of these differences. It was postulated that both pragmatic and cognit
ive skills impact on performance in the narrative genre; hence, defici
ts in these areas may have contributed to the observed performance def
icits. The nature of the deficits was considered consistent with subco
rtical plaque damage affecting fibre tracts between and within cerebra
l hemispheres. The findings of the present study suggest that further
research into narrative production in MS is warranted.