GAMMA-DELTA T-CELLS IN HUMAN CUTANEOUS IMMUNOLOGY

gamma delta T-Cells represent a minor subpopulation of T-lymphocytes i n man and their rule in normal and diseased human skin is unknown. Thi s article is a comprehensive review of T-lymphocytes bearing the gamma delta T-cell receptor in normal and pathological human skin. Firstly, we have documented the occurrence of gamma delta T-cells in normal sk in and in a range of reactive and malignant skin conditions. We have t hen discussed the experimental findings regarding the repertoire used by gamma delta T-cells in normal human skin and in cutaneous disorders with an increased percentage of gamma delta T-cells.